Pick a Topic:
Find info on a:
ClotCare complies with the HONcode standard for trustworthy health
ClotCare is a member organization of the Coalition to Prevent Deep Vein Thrombosis. Click here to learn more about the Coalition to Prevent Deep Vein Thrombosis and DVT Awareness Month, which is held each March.
Dabigatran (brand name Pradaxa) Special Storage and Stability Issues - Use the Blister Packs?
Henry I. Bussey, Pharm.D.
Dabigatran was recently approved for stroke prevention in atrial fibrillation in the U.S. The product is available in bottles of 60 capsules (a 30 day supply) or in blister packs which seal each capsule separately. The problem, apparently, is that the product deteriorates rather quickly when exposed to humidity. Capsules packaged in bottles are stable for only 30 days after the bottle is open and capsules should NOT be placed in any other container (such as weekly dosing containers as are often used to enhance adherence). I am told that the bottles contain a dessicant in the lid so that the product should remain stable for 30 days after initially opening the container as long as the lid is replaced tightly following each dose.
One solution to the stability problem, reportedly, is to use the blister pack packaging in which each dose is sealed separately. But care should be taken not to break the seal on a capsule before being ready to administer that dose. Whether blister packs pose an issue of "child resistant" packaging also should be considered.
For a more thorough discussion and further comment, see www.theheart.org/article/1181259.do?utm_campaign
ClotCare is a 501(c)(3) non-profit organization generously supported by your tax-deductible donations and grants from our industry supporters.
Click here to view full list of new postings
ClotCare Home | New Postings | Patient Postings | Clinician Postings | Join Our Email List | Useful Web Links
CE Opportunities | Training Programs | DVT & PE Stories | Editorial Board | Financial Support
About ClotCare | DVT Coalition | Donate to ClotCare | Contact Us
Key topics discussed on ClotCare include: Blood Clots | Deep Vein Thrombosis (DVT) | Pulmonary Embolism (PE) | Atrial Fibrillation (A. Fib or AF) | Heart Attack | Stroke | Transient Ischemic Attack (TIA) | Mini Stroke | Bleeding Complications | Vascular Surgery | Surgical Blood Clot Removal | Warfarin | Coumadin | Lovenox | Low Molecular Weight Heparin (LMWH) | Heparin | Anticoagulants | Plavix | Aspirin | Antiplatelets | Blood Thinners
Copyright 2000-2014 by ClotCare. All rights reserved.
Terms, Conditions, & Privacy | Image Copyright Information
19260 Stone Oak Parkway, Suite 101 | San Antonio, TX 78258 | 210-495-4335
Send comments to email@example.com.
Tuesday, April 28, 2015