ClotCare: Blood Clots, Stroke, Heart Attack
Thursday, December 14, 2017
Home   |   DVT/PE   |   Blood Clots   |   Coumadin/Warfarin   |   New Patients   |   Self Testing   |   Email List   |   Donate

Pick a Topic:

Find info on a:

We subscribe to the HONcode principles of the HON Foundation. Click to verify.
ClotCare complies with the HONcode standard for trustworthy health
information:
verify here.

ClotCare is a member of the Coalition to Prevent Deep Vein Thrombosis (DVT Coalition)  ClotCare is a member organization of the Coalition to Prevent Deep Vein Thrombosis. Click here to learn more about the Coalition to Prevent Deep Vein Thrombosis and DVT Awareness Month, which is held each March.

Could thromboembolism be considered an extra intestinal manifestation of inflammatory bowel disease (IBD)?

Chiara Piovella, MD
Provided by NATF
Posted on ClotCare January, 2008*

Reference: Solem CA, Loftus EV, Tremaine WJ, Sandborn WJ. Venous thromboembolism in inflammatory bowel disease. Am J Gastroenterol. 2004 Jan;99(1):97-101.

IBD refers to two chronic diseases that cause inflammation of the intestines: ulcerative colitis (UC) and Crohn's disease (CD). Patients suffering from IBD have a three-fold increased risk of venous thrombosis compared with matched controls. Importantly, thromboembolic disease is a significant cause of morbidity and mortality in patients with IBD.

The results of this retrospective study confirm that the IBD cohort compared to the general population had, in fact, a significantly increased rate of venous thromboembolism (VTE). 98 cases of IBD, 59 UC patients and 39 CD patients (identified between 1991 and 2001 at Mayo Clinic Rochester) who had developed a deep venous thrombosis (DVT) and/or a pulmonary embolism (PE) were analyzed.

The results suggested that the extent and activity of the IBD are highly associated with thromboembolic risk.

The authors, despite a very limited observational experience, suggest that colectomy per se is not protective from recurrent thrombembolic disease and that VTE is not an indication for an invasive procedure, particularly in UC patients.

However, the exact mechanism explaining the initiation of thrombosis remains unclear. It is likely to be a multifactorial process. Reported abnormalities include activation of markers of the coagulation cascade, disturbed fibrinolysis, and the activation of platelets. The contribution of thrombophilic disorders such as factor V Leiden, prothrombin gene mutations, and hyperhomocysteinaemia are discussed, but their role in thrombosis associated with IBD has remained unclear.

Nevertheless, patients suffering from this condition are often exposed to high-risk situations such as hospitalization, immobilization, or invasive procedures. Even if long term anticoagulation is contradicted (high bleeding risk), temporary low-dose prophylactic anticoagulation should be strongly considered.


Dr. Piovella completed her medical Internship, Residency, and Fellowship in Internal Medicine at the I.R.C.C.S Policlinico San Matteo in Pavia, Italy. She worked as a fellow in the Thromboembolic Disease Unit of Policlinico San Matteo in Pavia. Her major research effort this past year has been related to heparin-induced thrombocytopenia. Dr. Piovella is currently a Venous Thromboembolism Research Group Fellow.

This posting originally appeared on the website of the North American Thrombosis Forum (NATF) and has been provided on ClotCare with NATF's permission. See www.natfonline.org for more information about NATF.

Ask a question about blood clots or anticoagulant medications Have questions? Ask ClotCare. Send questions by email to webmaster@clotcare.org.

ClotCare is a 501(c)(3) non-profit organization generously supported by your tax-deductible donations and grants from our industry supporters.

Blood Clot Activities Calendar

New Postings:

Questioning Approval of the Watchman Device for Atrial Fibrillation.

How Should We Prevent Blood Clots Following Arthroscopic Knee Surgery? Cynthia’s Story and a Limited Discussion of the Literature

Stroke, A Caregiver's Story

Click here to view full list of new postings
ClotCare Home | New Postings | Patient Postings | Clinician Postings | Join Our Email List | Useful Web Links
CE Opportunities | Training Programs | DVT & PE Stories | Editorial Board | Financial Support
About ClotCare | DVT Coalition | Donate to ClotCare | Contact Us
Key topics discussed on ClotCare include: Blood Clots | Deep Vein Thrombosis (DVT) | Pulmonary Embolism (PE) | Atrial Fibrillation (A. Fib or AF) | Heart Attack | Stroke | Transient Ischemic Attack (TIA) | Mini Stroke | Bleeding Complications | Vascular Surgery | Surgical Blood Clot Removal | Warfarin | Coumadin | Lovenox | Low Molecular Weight Heparin (LMWH) | Heparin | Anticoagulants | Plavix | Aspirin | Antiplatelets | Blood Thinners
Copyright 2000-2014 by ClotCare. All rights reserved.
Terms, Conditions, & Privacy | Image Copyright Information
19260 Stone Oak Parkway, Suite 101 | San Antonio, TX 78258 | 210-495-4335
Send comments to webmaster@clotcare.org.
Thursday, December 14, 2017